Evidence library

Find the paper. See the study context.

Review ChondroFiller® Liquid research and structured Mytocel MSK® records with cohort size, study design, follow-up, population and limitations kept visible.

Current library

11ChondroFiller® papers

09Mytocel publications

3structured clinical records

Only published records are presented as published evidence. Study design and limitations should be considered before interpreting outcomes.

Mytocel MSK® · complete index

Nine publications, separated by evidence type.

Scientific reviews, pre-clinical work and clinical reports are identified before the title. Each record opens at its position in the supplied 116-page scientific booklet.

01Scientific reviewTissue regeneration: an overview from stem cells to micrograftsAstarita C, Arora CL, Trovato L · 2020Biological foundations and the distinction between stem cells and micrografts.Open study 02In vitro and in vivoAlar-nasal cartilage autologous micrografts and the Rigenera protocolCeccarelli G, Gentile P, Marcarelli M, et al. · 2017Cartilage micrograft preparation and osteochondral-lesion context.Open study 03Pre-clinical studyIntra-articular autologous cartilage micrografts for osteochondral repairDesando G, Grigolo B, Pereira AD, et al. · 2021Histological assessment in a rat osteochondral-defect model.Open study 04Preliminary clinical studyBiostimulation of knee cartilage using autologous micrograftsDorta A, Baroni A, et al. · 2018Early clinical experience in osteochondral lesions of the knee.Open study 05Three-year case seriesCartilage micrografts for knee chondropathy: three-year follow-upMarcarelli M, Zappia M, Rissolio L, et al. · 2021Clinical scores and MRI measurements in a small uncontrolled cohort.Open study 06Prospective observational studyNon-arthroscopic autologous cartilage micrografting for knee osteoarthritisTsoukas D, Muntean I, Simos C, et al. · 2023Patient-reported outcomes after a single procedure in a small cohort.Open study 07Clinical reportAutologous grafts in avascular osteonecrosis of the femoral headMarcarelli M, Fiammengo M, Trovato L, et al. · 2019Application of autologous grafts in a femoral-head indication.Open study 08Rationale and pre-clinical evidenceAutologous cartilage micrografts in cartilage repairViganò M, Tessaro I, Trovato L, et al. · 2018Cell viability, tissue-specific components and cartilage-repair rationale.Open study 09Pilot studyAutologous micrografting technology in managing osteoarthritis painHelito C, Pessei V, Zaniboni C, et al. · 2024Twelve-month outcomes in a ten-patient uncontrolled pilot cohort.Open study

Mytocel MSK®

Five clinical records, examined in greater detail.

Search evidenceStudy type

Showing 3 of 3 records

Mytocel MSK®Pilot studyn=1012 months

Efficacy of Autologous Micrografting Technology in Managing Osteoarthritis Pain

Helito CP, Pessei V, Zaniboni C, Muntean I. Bioengineering, 11(11):1119 (2024).

Population

Adults with knee osteoarthritis, Kellgren–Lawrence grades 2–4

Study context

The study followed clinical outcome measures after an autologous cartilage micrograft procedure using Rigenera technology.

Limitations

Small pilot cohort without a control group. Findings should be interpreted as preliminary and in the context of the study design.

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Mytocel MSK®Prospective observational studyn=1012 months

Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis

Tsoukas D, Muntean I, Simos C, Sabido-Vera R. Bioengineering, 10(11):1294 (2023).

Population

Adults with knee osteoarthritis across Kellgren–Lawrence grades 1–4

Study context

The cohort was assessed using clinical examination and patient-reported outcome measures after a single procedure.

Limitations

Small uncontrolled observational cohort with no comparator group. It cannot establish comparative effectiveness or causation.

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Mytocel MSK®Case series / follow-up studyn=83 years

Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy

Marcarelli M, Zappia M, Rissolio L, Baroni C, Astarita C, Trovato L, Graziano A. Journal of Clinical Medicine, 10(2):322 (2021).

Population

Adults with grade II–III knee chondropathy

Study context

The report followed clinical scores and standardised MRI measurements after autologous cartilage micrografting.

Limitations

Very small uncontrolled case series. The long follow-up is useful context, but the design does not support broad comparative claims.

View publisher record

ChondroFiller® Liquid

ChondroFiller® Liquid research for professional appraisal.

These documents are presented as source material for professional appraisal. Their inclusion does not imply equal study design, evidence strength or applicability.

Research paperResearch paperCell-free approachResearch material on the cell-free collagen-matrix approach.

Research paperResearch paperSafety of ChondroFillerProfessional material covering ChondroFiller safety and clinical use.

Research paperResearch paperCollagen matrix for cartilage repairResearch material on collagen matrices in cartilage repair.

Research paperResearch paperFemoroacetabular impingementClinical material relating to femoroacetabular impingement.

Research paperResearch paperRegeneration of cartilage defectsResearch material on the treatment of cartilage defects.

Research paperResearch paperHip defectsProfessional material covering hip cartilage defects.

Research paperResearch paperOsteoid osteomaClinical material concerning osteoid osteoma and joint-surface restoration.

Research paperResearch paperAnimal studyPre-clinical research material for professional appraisal.

Research paperResearch paperNeedle and curette techniqueTechnique material for professional review.

Research paperResearch paperBehaviour of human cartilageResearch material concerning human cartilage behaviour.

Research paperResearch paperArthritis of the thumbClinical material relating to thumb-joint applications.

Interpretation guardrails

What this library does not do.

It does not turn an uncontrolled cohort into comparative evidence.
It does not generalise beyond the population and follow-up described by the authors.
It does not replace critical appraisal, current instructions or professional clinical judgement.

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